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How Stress Messes With Your Metabolism + How To Fix It, According To An RD

Ali Miller, R.D., L.D., CDE
November 13, 2019
Ali Miller, R.D., L.D., CDE
Registered Dietitian & Certified Diabetes Educator
By Ali Miller, R.D., L.D., CDE
Registered Dietitian & Certified Diabetes Educator
Ali Miller R.D., L.D., CDE is a Registered Dietitian and Certified Diabetes Educator with a naturopathic background.
3 Ways Stress Messes with Your Hormones and 5 Foods to Fix It
Image by mbg Creative
November 13, 2019

Whether emotional, cognitive, physical, or environmental, stress is inevitable. It can be perceived as negative, such as from a divorce, as well as positive, such as from a new baby or taking on a new career. No matter which type it is, if stress becomes chronic, it can disrupt hormonal balance and throw off your metabolism.

I've talked in depth about the role of stress on your digestion and how stress and anxiety can affect gut health and microbiome balance, but here, I am going to focus on hormones. So, let's dive in.

Understanding the stress response.

Let's start with the basics: the sympathetic and parasympathetic nervous systems. Both are part of the autonomic nervous system, a regulatory center that influences organs, vessels, glands, genitals, and digestive system, driving the survival reactive and regulatory involuntary functions of the body.

The parasympathetic system manages metabolism, reproductive health, sleep and energy cycles, body temperature, and fluid regulation and is often referred to as the "rest and digest" state while the sympathetic nervous system is the reactive survival response is often referred to as "fight or flight."

When the body is under stress, it favors the sympathetic nervous system1. This drives the activity of the hypothalamic-pituitary-adrenal axis (HPA axis), stimulating the adrenal glands to release cortisol and stress-responding neurotransmitters. 

In a balanced body, cortisol serves to provide negative feedback2 to the HPA-axis, telling it the stress-responding chemical has been released and the body can go back to its regulatory, parasympathetic state. However, in a chronic stress state, the body does not shift from sympathetic mode back into parasympathetic, instead continuing to fire stress response chemicals while suppressing the regulatory function.

Unfortunately, in our modern lifestyle, stressors are plentiful and constant. This is where we start to see the influence of chronic stress on hormone balance. 

How stress influences metabolic hormones.

Hormones serve as regulatory substances, providing stimulation or repression of signals based on receptor function and balance in the body. Our metabolism, sleep, sexual hormone function, and mood are all influenced by the hormone regulation of our autonomic nervous system and balance of our HPA-axis. Chronic stress can disrupt hormone regulation and cause major metabolic consequences.

Thyroid hormone regulation

Let's start with the thyroid. When the body is at rest, the hypothalamus releases thyroid-releasing hormone (TRH). In response, the pituitary gland releases thyroid-stimulating hormone (TSH), increasing thyroid hormone production and regulation.

But, in times of stress, the adrenals are prioritized over thyroid regulation, and energy is shunted to them. What's more, cortisol, which is released in response to stress, can interfere with how the inactive thyroid hormone, T4, is converted to the active form, T3. In addition, stress can interfere3 with T3 expression, all of which puts the brakes on metabolism.

The body has these mechanisms at play because if you were in a survival situation, say running from a predator, it would not be a good time to burn calories. However, the chronic stressors we are now battling are often not physical, which can drive weight gain and sluggish metabolism.

Blood sugar

The stress hormone cortisol is a glucocorticoid, a hormone that produces blood sugar from the liver and reduces sensitivity on insulin receptors. Therefore, cortisol increases blood sugar levels, insulin resistance4, and drives body fat storage.

Cortisol does have some beneficial properties, like serving to reduce inflammation5 and enhance survival. But when chronically elevated, it can drive blood sugar imbalance and weight gain.


Another metabolic hormone influenced by stress is leptin, a satiety hormone. Leptin is produced by our fat cells in response to body fat storage levels and fat consumption. It regulates energy balance by inhibiting hunger to encourage the use of stored fat for fuel.

Leptin generally tells the body when it is fed, supporting healthy metabolism. In a chronically stressed state, though, the body can become resistant to the signaling of leptin6, leading to overeating and weight gain.

Sex hormones

When cortisol levels are elevated, it can disrupt the metabolism of sexual hormones7 both directly and indirectly. First, by interfering with the way the liver excretes excess circulating hormone and second by interfering with the production and conversion of sexual hormones.

Essentially, if the body is under chronic stress, it will prioritize survival, not regulation. This is why stress can be heavily linked to fertility struggles. The body wants to feel safe to ensure it can support the growth and development of a child. When a woman is chronically stressed, estrogen can be suppressed8. In men, testosterone can be inhibited by stress9, driving impotence and loss of libido.

5 foods that support metabolic balance.

Using a food-as-medicine approach to support your body's stress response will also favorably influence the metabolism. The foods below all have an ability to influence thyroid, blood sugar, metabolic, or sexual hormone balance while serving to balance your mood and support stress resilience:


Seaweed (nori, wakame, kelp)

Seaweed is rich in iodine, an essential mineral for thyroid hormone production, and magnesium, to provide neuromuscular relaxation. Seaweed is also rich in tryptophan, an amino acid that is used to make serotonin, serving to regulate mood and reduce stress response.


Citrus (orange, lemon, lime)

Citrus is a great source of vitamin C, an antioxidant that is most concentrated in the adrenal glands. Vitamin C plays a role in the regulation of cortisol metabolism and production. The incorporation of citrus also provides anti-inflammatory and antihistamine bioflavonoids, such as hesperidin, rutin, and quercetin, to synergistically work with cortisol to reduce excess demands. 



Flax is rich in the omega-3 fatty acid alpha-linolenic acid (ALA), which can be stored in adipose tissue. ALA influences the expression of hormones on fat cells, like leptin10, supporting healthy appetite regulation. Flax has also been shown to favorably improve insulin resistance11.



Broccoli is rich in indole-3-carbinol (I3Cs)12, which can favorably modulate the metabolism of estrogen, reducing dominance or excess while providing antioxidant effects. As a source of chromium and fiber in the diet, broccoli can also aid in blood sugar regulation and reduced insulin resistance. Cruciferous vegetables, including broccoli, also provide a source of sulfur in the diet, which promotes detoxification and reduces inflammation.



The main compound in turmeric, curcumin, is an anti-inflammatory, immune-boosting antioxidant that can reduce oxidative stress in the body and brain. Thus, it reduces chronic stress impact and the need for continued cortisol demands. Curcumin boosts brain-derived neurotrophic factor (BDNF) levels13, which can aid in mood stability and stress tolerance. 

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Ali Miller, R.D., L.D., CDE author page.
Ali Miller, R.D., L.D., CDE
Registered Dietitian & Certified Diabetes Educator

Ali Miller R.D., L.D., CDE is a Registered Dietitian with a naturopathic background and a contagious passion for using nutrients and food as the foundation of treatment protocols and programs. She received her bachelor's in nutrition and dietetics from Bastyr University. She is the author of the cookbook Naturally Nourished: Food-as-Medicine for Optimal Health, The Anti-Anxiety Diet, and The Anti-Anxiety Cookbook.

Her Food-As-Medicine philosophy is supported by up-to-date scientific research for a functional integrative approach to healing the body. Ali is a certified diabetes educator (CDE) and renowned expert in the ketogenic diet with over a decade of clinical results using a unique whole foods approach tailored to support thyroid, adrenal and hormonal balance.

Ali’s message has influenced millions through the medical community and media with television, print, and her award winning podcast, Naturally Nourished. Ali’s expertise can be accessed through her website: offering her blog, podcast, virtual learning, and access to her practice and supplement line Naturally Nourished.