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These 19 Liver Detox Supplements Are The Best On The Market

The 19 Best Supplements To Support Liver Health & Detoxification*
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Thanks to an increase in modern-world toxins, not to mention the day-to-day stresses of normal cellular processes, our liver is exposed to heavier toxin loads and could use a little extra support. When toxins are not converted into easily removable compounds within the liver, they can stay around in the body longer and may take an alternative route to the brain, nerves, various glands, or other biological tissues—all of which can lead to health implications down the road. (Yikes!)

True detoxification means taking daily actions to help your body's natural detox pathways through diet, exercise, sleep, hydration, and—yes, smart supplementation.*

Quick List
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What does the liver do?

The liver is a large vital organ located in the abdomen that performs over 500 biological tasks to promote everything from healthy skin, digestion, and detoxification to sufficient energy levels. As the body's primary detox organ, the liver eliminates toxins we take in from our environment and lifestyle (e.g., chemicals, pollutants, heavy metals, alcohol, etc.) by biotransforming them into water-soluble compounds that can be excreted through urine and by incorporating fat-soluble compounds into bile for elimination via feces.

Though the liver is just one part of the body's complex detoxification pathways, its health and function are essential for optimal detoxification, whole-body health, and even longevity.

How liver supplements work.

While many detox products are designed to be a temporary solution or "cleanse" for a season, they're often tough on the body and their benefits are fleeting. Unlike detox drinks and liquid cleanse diet fads, the best liver detox supplements help bolster liver health and function 24/7 with targeted bioactives to promote liver and whole-body detoxification pathways.*

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What to look for in a quality liver health supplement.

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The liver and its functions can be somewhat elusive to the average person, but you better believe that your liver is working hard every day to filter compounds for the rest of the body to use (or easily eliminate). We know how confusing the dietary supplement market can be, so we asked our vice president of scientific affairs, Ashley Jordan Ferira, Ph.D., RDN, to highlight the top five criteria to consider when choosing the best liver detox supplement.

Whether you're trying to figure out what to look for in a liver supplement or hoping to select one of the products on our list, we hope these five factors help you find the right supplement to support your personal detox pathways and optimize your liver health:

1. Biological support for liver detox pathways

Detoxification is complex—and the liver is right in the middle of it all. Choosing a comprehensive liver detox supplement that supports various aspects and angles of detoxification (such as detox phase I and II, which occur in the liver) and helps the body bind to and remove toxins is key. 

Products that contain antioxidants (especially glutathione, aka the body's "master antioxidant") help maintain oxidative balance, which is crucial for optimal liver function.* Find a supplement that bolsters sufficient antioxidant levels to combat free radicals (which are both a byproduct of liver detoxification pathways and the result of normal biological functions) and promote healthy redox balance (i.e., antioxidants balancing out oxidants).*

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2. Multi-system detox support

Although the liver is a biological detox VIP, detoxification is a whole-body process that involves multiple organ systems. Naturally, your detox supplement should have ingredients (e.g., nutrients, botanicals, and bioactives) that provide comprehensive support that aids cellular, organ, and whole-body cleanup activities.* 

For example, a supplement that includes antioxidant ingredients offers comprehensive detox support by promoting oxidative balance in the main organs of elimination (i.e., liver, kidneys, skin, gastrointestinal tract, and lymph) and throughout the body.*

3. Science-backed ingredients

According to Ferira, your liver detox supplement should include meaningful doses of science-backed ingredients—i.e., ingredients that have plausible biological mechanisms or evidence of clinically shown liver support.*

Some examples of nutrients, plant compounds, and bioactives that support liver function and detoxification include but are not limited to:* 

  • Antioxidants: glutathione, quercetin, CoQ10, etc.
  • Botanicals: milk thistle, turmeric, artichoke, dandelion root, etc.
  • Amino acids and precursors for amino acids: cysteine, taurine, N-acetyl-L-cysteine (NAC), etc. 
  • Essential nutrients: vitamin A, vitamin C, vitamin E, B vitamins, selenium, zinc, manganese, etc.
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4. Sustainable detox support

The vast majority of short-term, overhaul cleanses simply don't make sense (and can be quite taxing on mental health and psychological well-being). "Our bodies detox 24/7, so why the heck aren't we supporting that?" asks Ferira. 

Most of the detox supplements included on our list are meant to be taken every day and provide daily detoxification support.* That said, there is a time and a place for "resetting" your detox pathways, so we included two short-term cleanse and reset options as well, in case you're looking for a detox approach that will hit your body's "refresh" button.

5. Quality sourcing & reputation

When it comes to dietary supplements, quality and transparency are of the utmost importance. If you're thinking about adding a liver detox supplement (or any new supplement) to your routine, make sure you do your research on the company's sourcing, quality, and reputation. The product should prioritize purity and potency, and the brand should be transparent about what's in their product and where it comes from.

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Best liver detox supplements.

Best overall: mindbodygreen daily detox+

With a curated entourage of powerful bioactives, botanicals, and nutrients, mbg's daily detox+ delivers 360-degree, whole-body detoxification support. Our premium formula actively fuels detox pathways, promotes toxin filtering and removal, and combats oxidative stress thanks to its synergistic and innovative design. Setria® glutathione (aka the master antioxidant) is at the helm, cruising tissues to clear toxins and restore equilibrium, while each additional ingredient synergizes glutathione by promoting its synthesis (milk thistle), bolstering healthy levels in the body (acerola vitamin C), helping to activate vital enzymes (selenium), and promoting regeneration (NAC). Consider daily detox+ your personal cleanup crew that works round the clock to support your body's 24/7 detoxification. Did we mention it's vegan and free of GMOs, gluten, soy, dairy, and all major food allergens?*

daily detox+, mindbodygreen ($59/month)

Best overall: mindbodygreen daily detox+
mindbodygreen

Best milk thistle complex: Integrative Therapeutics Super Milk Thistle® X

Milk thistle has been used for centuries to support liver health and function. This is thanks to milk thistle's phytonutrient compound silymarin, which helps protect liver cells via antioxidant and anti-inflammatory actions in the body. Dandelion leaf and artichoke extract help promote bile production, while licorice root extract provides additional anti-inflammatory properties. This botanical-packed, liver-centric formula is vegan and free from gluten, dairy, and soy.*

Super Milk Thistle® X, Integrative Therapeutics ($44)

Best milk thistle complex: Integrative Therapeutics Super Milk Thistle® X
mbg Creative / Integrative Therapeutics

Best mushroom blend: Cymbiotika Organic Longevity Mushrooms

Who doesn't love medicinal mushrooms? Packed with six powerful mushroom varieties—cordyceps, lion's mane, reishi, shiitake, turkey tail, and king trumpet—Cymbiotika's liposomal mushroom formula is unique. Diverse fungi offer beta-glucans, prebiotics, minerals, B vitamins, amino acids, and more that promote liver function and whole-body health. Squeeze the entire contents of this 40-calorie, sugar-free, fudge-like syrup onto your yogurt in the morning, your ice cream at night, or directly into your coffee or milk for a sweet liver-supporting treat.*

Organic Longevity Mushrooms, Cymbiotika ($60)

Best mushroom blend: Cymbiotika Organic Longevity Mushrooms
mbg Creative / Cymbiotika

Best with TUDCA: Revive Liver

Tauroursodeoxycholic acid (aka TUDCA) is a soluble bile salt that has been found to promote liver health and nurture healthy bile flow. While Revive's 300 milligrams of TUDCA earned its superlative, this bile salt isn't the only ingredient in the formula that promotes liver function: NAC and milk thistle both support healthy glutathione levels. Meanwhile, astragalus, ginseng, and black pepper extracts deliver additional antioxidant actions. The four-capsule serving size takes some commitment, but we're fans of the formula.*

Liver, Revive ($55)

Best with TUDCA: Revive Liver
mbg Creative / Revive

Best softgel: Gundry MD Complete Liver Support

Gundry MD's liver supplement delivers three herbal compounds to nurture liver health and function: an entire gram of orange peel extract for its antioxidant and anti-inflammatory properties, plus milk thistle to protect and renew liver cells and dandelion root to detoxify the liver and promote bile production. This botanical formula supports the body's natural detox pathways and helps promote immune function and a healthy metabolism—in two daily softgels!*

Complete Liver Support, Gundry MD ($39)

Best softgel: Gundry MD Complete Liver Support
mbg Creative / Gundry MD

Best tablet: New Nordic Active Liver™

Featuring globe artichoke leaf (to help protect the liver and promote tissue integrity and healthy bile flow), antioxidant powerhouse turmeric root extract, and a potent dose of the phytonutrient silymarin extract from milk thistle, the bioactives in Active Liver™ bolster liver health and function. This vegan, dairy-free, gluten-free, GMO-free supplement takes ingredients straight from nature and delivers them in one daily tablet for a no-fuss approach to liver support.*

Active Liver™, New Nordic ($17)

Best tablet: New Nordic Active Liver™
mbg Creative / New Nordic

Best liquid: Zuma Nutrition Liver Detox & Support™

Harvested in Idaho, this unique blend of organic, wildcrafted herbs was formulated to support the liver's natural detox pathways and promote optimal liver health and rejuvenation. Vegan, organic, and pesticide-free, this water-soluble liquid supports absorption of liver-cleansing oleuropein derived from olive leaf (which delivers powerful antioxidant, anti-inflammatory, and liver-protective actions), liver-loving silymarin from milk thistle, potent antioxidant quercetin, and more. (All in just one daily dropper!)*

Liver Detox & Support™, Zuma Nutrition ($60)

Best liquid: Zuma Nutrition Liver Detox & Support™
mbg Creative / Zuma Nutrition

Best with artichoke: Swisse Liver Detox

Derived from globe artichokes grown in Spain, the 40-milligram dose of artichoke leaf extract is the star of the show in this supplement. Milk thistle and turmeric round out the list of antioxidant ingredients to provide a detox formula that delivers liver protection, renewal, and overall health and function. If those highlights weren't exciting enough, Swisse's Liver Detox is also vegan, vegetarian, and free from artificial flavors and sweeteners, sugar, lactose, and gluten.*

Liver Detox, Swisse ($36)

Best with artichoke: Swisse Liver Detox
mbg Creative / Swisse

Best greens detox powder: mindbodygreen organic veggies+

We don't mean to brag, but mbg's vegan greens powder delivers a USDA-certified organic whole foods blend with 31 powerhouse ingredients that promote digestion, gastrointestinal health, and detoxification. With everything from organic root and sea vegetables, leafy greens, and herbs to berries, digestive enzymes, and pre- and probiotics, organic veggies+ offers a full array of botanicals and fiber to support liver and whole-body detoxification. Cruciferous veggies broccoli and green cabbage and anti-inflammatory ginger and turmeric are especially showing your liver some love.*

organic veggies+, mindbodygreen ($49/month)

Best greens detox powder: mindbodygreen organic veggies+
mindbodygreen

Best protein detox powder: Seeking Health Optimal Detox

Nineteen amino acids, a plant-based pea and rice protein blend, potent antioxidants—the list of great ingredients in this protein powder go on and on. Meanwhile, the list of things not included (milk, eggs, shellfish, tree nuts, peanuts, wheat, soy, gluten, yeast, and GMOs) is equally impressive. When it comes to liver support, ellagic acid from pomegranate, NAC, watercress, and sodium sulfate especially help bolster detox pathways and promote healthy liver function. Just blend, shake, or stir two scoops of this vanilla powder into water and/or a smoothie to support your body's detoxification.*

Optimal Detox, Seeking Health ($65)

Best protein detox powder: Seeking Health Optimal Detox
mbg Creative / Seeking Health

Best with triphala: Organifi Liver Reset

Translated to "three fruits" in Sanskrit, triphala is an Ayurvedic blend of antioxidant-rich dried fruits that supports whole-body detoxification and healthy liver function. Organifi's Liver Reset features 300 milligrams of triphala alongside other liver-protective botanical extracts, such as milk thistle, dandelion root, and artichoke leaf. It's also worth mentioning that this liver reset supplement boasts a very short list of excipients (aka other ingredients).*

Liver Reset, Organifi ($38)

Best with triphala: Organifi Liver Reset
mindbodygreen / Organifi

Best liver + GI support: Pure Encapsulations Liver-G.I. Detox

When it comes to detoxification, the small and large intestines have a big role to play in the binding and removal of toxins. So, it only makes sense that Pure Encapsulations created Liver-G.I. Detox to support detox pathways that involve both the liver and the gastrointestinal tract. This packed ingredient list includes alpha-lipoic acid (ALA), NAC, turmeric, broccoli sprout concentrate, milk thistle, artichoke, chlorella, and amino acids (including taurine, gut-loving glutamine, and glutathione precursor methionine, and glutathione building block glycine). Whether you're looking for liver-protective and antioxidant properties or wanting to maintain the integrity and health of your intestinal barrier, this gluten- and GMO-free supplement has you covered.*

Liver-G.I. Detox, Pure Encapsulations ($53)

Best liver + GI support: Pure Encapsulations Liver-G.I. Detox
mbg Creative / Pure Encapsulations

Best botanical blend: Gaia Herbs Liver Cleanse

Looking for a high-quality herbal supplement that supports sustainability, the environment, and your liver? As a certified B Corp with a transparent commitment to purity the environment, Gaia Herbs has got you covered. With botanicals like milk thistle, dandelion root, turmeric root, ginger root, burdock root, and more, this plant-packed supplement helps support detoxification and elimination pathways, promote bile production, and cleanse the liver. (And it's vegan and dairy-, gluten-, and soy-free, to boot!)*

Liver Cleanse, Gaia Herbs ($30)

Best botanical blend: Gaia Herbs Liver Cleanse
mbg Creative / Gaia Herbs

Best high-potency silymarin: Metabolic Maintenance Silymarin

With 300 milligrams of the liver-famous phytochemical silymarin in a singular vegetarian capsule, this no-fuss, high-potency silymarin supplement gets straight to the point. Derived from milk thistle seed, silymarin supports liver health by helping to stabilize liver cell membranes and combating oxidative stress (thanks to its inherent antioxidant properties). Free from dairy, peanuts, tree nuts, and gluten, this supplement is frill-free and ready to promote healthy liver function.*

Silymarin, Metabolic Maintenance ($50)

Best high-potency silymarin: Metabolic Maintenance Silymarin
mbg Creative / Metabolic Maintenance

Best NAC complex: Live Conscious LiverWell™

NAC is a precursor to master antioxidant glutathione and contains antioxidant properties of its own. With 800 milligrams of NAC, LiverWell™ is serious about supporting antioxidant and detoxifying pathways in the body. This vegan formula includes ALA (another potent antioxidant), milk thistle, selenium, and zinc, all of which work together to help protect the liver and maintain redox balance. Live Conscious products are thoroughly tested to ensure purity and give you peace of mind.*

LiverWell™, Live Conscious ($30)

Best NAC complex: Live Conscious LiverWell™
mbg Creative / Live Conscious

Best short-term cleanse tea: Flora Flor•Essence®

It’s clear that herbs are BFFL (best friends for livers) in this gentle detox tea. The eight botanicals included in Flor•Essence® support elimination pathways and the removal of toxins—both in the liver and on a whole-body level. Antioxidant herbal ingredients like watercress and organic burdock root, sheep sorrel, slippery elm, kelp, and rhubarb root help fight free radicals and combat oxidative stress, while red clover blossom works to eliminate toxins from blood and blessed thistle (not be confused with milk thistle) helps stimulate bile production. This vegan, GMO-free tea comes in 17- and 32-ounce bottles—just measure two ounces into a mug and add hot water to enjoy!*

Flor•Essence®, Flora ($33)

Best short-term cleanse tea: Flora Flor•Essence®
mbg Creative / Flora

Best short-term cleanse bundle: Your Super Detox Bundle

As a general rule of thumb, we recommend daily detoxification support through diet, lifestyle, and supplementation rather than a "quick fix" detox solution. After all, drinking a juice cleanse a few times a year isn't nearly as supportive of your detox pathways as hydrating, nourishing your body with nutrient-dense foods, and engaging in detox-supporting activities (like exercise) is. That said, there is definitely a time for a short-term cleanse, and Your Super offers a great option if that's what you're looking for. With ingredients sourced from small farmers, this five-day cleanse offers five different plant-based powders to rejuvenate your detoxification pathways and energy levels.*

Detox Bundle, Your Super ($170)

Best short-term cleanse bundle: Your Super Detox Bundle
mbg Creative / Your Super

Best short-term reset: Clinique La Prairie PURITY Daily DTX

For a two-month reset, consider Clinique La Prarie's PURITY Daily DTX. Unlike a three- or five-day cleanse, this detox supplement is meant to accompany holistic detoxification practices (e.g., eating a clean, plant-based diet; increasing hydration; sweating through exercise and/or in an infrared sauna; etc.) over an eight-week stretch. Featured ingredients include chlorella (promotes removal of heavy metals), grapeseed extract (anti-inflammatory properties help protect the liver), dandelion extract (supports bile production), and aronia berry extract (bolsters overall liver health and function). Take two capsules each morning with water to support the body's detox processes during your period of restoration.*

PURITY Daily DTX, Clinique La Prairie ($340)

Best short-term reset: Clinique La Prairie PURITY Daily DTX
mbg Creative / Clinique La Prairie

Best budget: Life Extension Glutathione, Cysteine & C

With 500 milligrams of vitamin C, a modest 50 milligrams of glutathione, and 200 milligrams of cysteine, this antioxidant-focused supplement from Life Extension gives you bang for your buck. Cysteine directly supports phase II detoxification activities in the liver, while vitamin C and glutathione deliver antioxidant support to help maintain redox balance. Together vitamin C and cysteine aid the master antioxidant's activity—vitamin C bolsters glutathione levels in the body, while amino acid cysteine promotes glutathione production. Not bad for $17, huh?*

Glutathione, Cysteine & C, Life Extension ($17)

Best budget: Life Extension Glutathione, Cysteine & C
mbg Creative / Life Extension

The takeaway.

The liver certainly isn't the only detoxification organ, but it's no doubt the most famous. You'll notice that this list of supplements doesn't have one go-to ingredient to support liver health but rather a smorgasbord of bioactives that promote liver detoxification from every angle.* 

If you're thinking about adding one of these liver supplements to your daily routine for everyday detox support, make sure to talk to a health care provider first. Whether you're using this guide to navigate the vast market of liver supplements or are already sold on one included in this list, we hope you find the detox product that complements your lifestyle and takes care of your liver health needs.*

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Supports daily detoxification*

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daily detox+

Supports daily detoxification*

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★ ★ ★ ★ ★
(13)
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