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Caffeine Supports Focus, Memory, Antioxidant Activity, Athletic Performance & More*

Morgan Chamberlain
Author:
July 01, 2025
Morgan Chamberlain
Former mbg Supplement Editor
By Morgan Chamberlain
Former mbg Supplement Editor
Morgan Chamberlain is mindbodygreen's former supplement editor. She graduated from Syracuse University with a Bachelor of Science degree in magazine journalism and a minor in nutrition.
Drinking Coffee
Image by Kike Arnaiz / Stocksy
July 01, 2025
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Whether you make your own pour-over, head to your local coffee shop for matcha, or enjoy a midday tea, caffeine is an integral part of many people's days. When you've got things to do and places to be, the energizing effects of caffeine can be a lifesaver.

The benefits of caffeine aren't limited to energy, though. Ahead, learn about its effects on the body and mind (from brain health to athletic ability) plus how to tell you've had too much.

What is caffeine and how does it work?

Caffeine is a unique phytonutrient compound (or sometimes, a synthetic substance, depending on the source) that stimulates the central nervous system (CNS).* As a plant nutrient (aka phyto + nutrient), it's naturally found in more than 60 plants1, including coffee berries, coffee beans, tea leaves, guarana seeds, and cacao beans (i.e., chocolate).

In the body, caffeine sources like espresso and coffee stimulate your CNS (i.e., your brain and spinal cord) primarily by blocking adenosine receptors2, according to Isa Kujawski, MPH, RDN, registered dietitian nutritionist and founder of Mea Nutrition.*

A quick explainer: Adenosine is a neurotransmitter, aka a chemical messenger secreted by nerve cells (neurons). When it binds to specific receptors, adenosine slows down neural activity and makes you sleepy. Your levels of adenosine naturally increase the longer you're awake and drop while you snooze at night.

However, caffeine has a similar structure to adenosine—so much so that it can swoop in and bind to adenosine receptors.* It's a natural "antagonist" (turns out to be a useful thing) of the receptor. This temporarily prevents adenosine from attaching to said receptors, helping you feel more wakeful and alert.*

Benefits of caffeine

Here's what caffeine can do for your body and mind, according to experts and research:

1. Supports focus and mental clarity

In addition to blocking adenosine receptors, caffeine also activates the pituitary gland to make some adrenaline, says Kujawski. (Adrenaline is known as the "fight or flight" hormone, btw.) 

"This mimics our normal stress response, which increases our attention levels and gives us a burst of energy and alertness,"* explains Kujawski.

"Caffeine also indirectly stimulates the release of neurotransmitters such as dopamine, serotonin, and GABA,"* she adds. These "feel-good" neurotransmitters can help maintain attention3 and focus, making it easier to tackle your to-do list.

2. Helps support memory

According to a 2021 review in the journal Nutrientslow doses of caffeine can improve memory and cognitive performance, which may be due to its ability to bind to adenosine receptors (which also promotes dilation of blood vessels via nitric oxide pathways for blood flow to the brain), as well as its neuroprotective benefits4.* 

However, as a 2021 review in Neuroscience & Behavioral Reviews notes, caffeine's effects on memory5 might vary depending on individual demographics (i.e., age, sex, and caffeine metabolism rate) and memory type.

While more research will be useful to tease apart these personalized nuances more, clinical literature to date demonstrates caffeine's beneficial impact on both short-term and long-term memory6 in young and older adults.

3. Neutralizes free radicals

Did you know that caffeine has antioxidant properties7? "As with other antioxidants like vitamin C and resveratrol, caffeine has [the] ability to protect against free radicals,"* shares Ella Davar, R.D., CDN, registered dietitian and founder of Nutritionist Ella

Again, this brings us full circle to caffeine being a plant nutrient (phytonutrient), which often serves up antioxidant actions. This, of course, assumes your caffeine source is plant-derived, for example from a whole coffee cherry8 extract.

Caffeine's antioxidant characteristics help enhance our antioxidant defenses (i.e., combating and balancing free radicals), which in turn, promotes whole-body health.* In fact, according to a scientific review in Skin Pharmacology and Physiology9, these benefits even extend externally to the skin, where caffeine's antioxidant actions (i.e., in topical applications) can delay signs of aging.

4. Promotes multidimensional brain health

The antioxidant abilities of caffeine also nurture our brain.* Regulating oxidative balance10, after all, is essential for supporting healthy nerve cells and brain function. According to a 2020 scientific review11 from the Saudi Pharmaceutical Journal, caffeine also mitigates neural pathways and protects neurons, ultimately promoting overall brain wellness.*

As nutrition scientist Ashley Jordan Ferira, Ph.D., RDN explains, "Caffeine is actually multitasking on our behalf when it comes to brain benefits. Research demonstrates its multidimensional abilities to sustain attention and improve alertness12, enhance problem solving and creativity13, fuel mental alertness14, and even elevate mood15."*

Ferira further notes that, "with the right caffeine matrix (i.e., delivery technology), certain sustained caffeine ingredients from the Coffea plant species (coffee) have been shown to net an especially impressive array of productive brain benefits14 in the alertness and mood arenas while simultaneously combating the converse effects like mental tiredness, dip in mood, and jitters."* (You know, that no-so-fun caffeine "crash" phenomenon.)

5. Bolsters exercise performance

Whether you're training for a marathon or hitting up a HIIT class, caffeine is considered a stimulating ergogenic acid that can elevate your routine, physical energy, and performance.*

"Caffeine activates neural circuits and, in turn, the release of adrenaline,"* explains Kujawski. This dilates blood vessels and air passages, which increases blood flow and oxygen to your brain and muscles, she says. This effect, along with the energizing effects of caffeine, can help enhance overall athletic performance.*

Sources of caffeine

When it comes to the most common sources of caffeine, the amount in each serving can vary widely. It depends on many factors, including preparation technique and brewing time.

For example, the caffeine content of coffee beans depends on how long they've been roasted. Likewise, the longer black tea leaves are steeped, the more caffeine your tea will have. 

Here's how much caffeine you can find in common sources:

If you prefer to get a caffeinated energy boost from coffee, consider mindbodygreen's clean coffee+.

This organic, whole-bean blend is tested for mold, mycotoxins, heavy metals, and pesticides. This testing results in quality you can taste. And many customers rave about the jitter-free energy they experience.

You can also consume caffeine in supplements, either on its own or combined with other nootropic ingredients that support energy, focus, and concentration. This one is our favorite, but here's the full list of our expert-vetted picks.*

How much caffeine is too much?

For the average person, it's recommended to consume no more than 400 milligrams of caffeine per day, per the FDA23. That's equal to approximately four 8-ounce cups of brewed coffee. However, if you're sensitive to caffeine, your threshold will likely be lower.

"While 400 milligrams has demonstrated safety in healthy adults thanks to scientific research24, 200 to 300 milligrams is a more conservative daily limit that's considered a prudent approach for women who are pregnant25 or trying to become pregnant," shares Ferira.

It's also a good idea to consider your timing. According to Kujawski, caffeine can take up to 10 hours to completely wear off, so you should stop consuming it at least 10 hours before bedtime. (But again, everyone processes caffeine at different rates, so be sure to listen to your body.)

You should also make an attempt to reduce your caffeine intake if you start feeling uneasy, restless, or have physical discomfort in your head or chest. This might be your body trying to tell you that you've consumed too much caffeine.

Be mindful of your long-term consumption of caffeine, too. Over time, ingesting high amounts can mess with your sleep schedule, says Kujawski. Excessive amounts of caffeine can also affect your stomach, heart, and nervous system, so you'll want to enjoy the ingredient in moderation. If you're sensitive to caffeine, talk to your health care provider before consuming the ingredient in any form.

The takeaway

Caffeine stimulates the central nervous system by interacting with key neurotransmitter receptors and increasing vasodilation—these neuromodulatory pathways increase energy levels while promoting focus, alertness, mental clarity and concentration, cognitive and physical performance, and more.* Caffeine also has intrinsic antioxidant properties, which nurtures brain and whole-body health.*

If you are pregnant, breastfeeding, or taking medications, consult with your doctor before starting a supplement routine. It is always optimal to consult with a health care provider when considering what supplements are right for you.

25 Sources

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462044/
  2. https://www.ncbi.nlm.nih.gov/books/NBK519490/
  3. https://link.springer.com/article/10.1007/s00213-012-2917-4
  4. https://www.sciencedirect.com/science/article/pii/S0149763416300690?via%3Dihub
  5. https://www.sciencedirect.com/science/article/abs/pii/S0149763421004152
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202818/
  7. https://www.sciencedirect.com/science/article/abs/pii/S0969806X20302899?via%3Dihub
  8. https://www.mdpi.com/1420-3049/26/14/4306/htm
  9. https://pubmed.ncbi.nlm.nih.gov/23075568/
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193071/
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132598/
  12. https://journals.sagepub.com/doi/10.1177/0269881116668593
  13. https://www.sciencedirect.com/science/article/abs/pii/S1053810019303435?via%3Dihub
  14. https://www.sciencedirect.com/science/article/pii/S2666518221000231
  15. https://link.springer.com/article/10.1007/s00213-004-2104-3
  16. https://fdc.nal.usda.gov/fdc-app.html#/food-details/1104137/nutrients
  17. https://fdc.nal.usda.gov/fdc-app.html#/food-details/1104211/nutrients
  18. https://fdc.nal.usda.gov/fdc-app.html#/food-details/1104140/nutrients
  19. https://fdc.nal.usda.gov/fdc-app.html#/food-details/1104286/nutrients
  20. https://fdc.nal.usda.gov/fdc-app.html#/food-details/1104292/nutrients
  21. https://fdc.nal.usda.gov/fdc-app.html#/food-details/170272/nutrients
  22. https://fdc.nal.usda.gov/fdc-app.html#/food-details/167976/nutrients
  23. https://www.fda.gov/consumers/consumer-updates/spilling-beans-how-much-caffeine-too-much
  24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445139/
  25. https://www.acog.org/womens-health/experts-and-stories/ask-acog/how-much-coffee-can-i-drink-while-pregnant
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