What Exactly Is Beta-Glucan & What Are Its Notable Health Benefits?
There's a lot of buzz around fiber, but it isn't a singular nutrient. While all fibers are types of carbohydrates, there are several varieties. One example is beta-glucans—bioactive plant compounds that have been linked to gut, heart, and immune health.
We spoke with experts to help break down the benefits of beta-glucans, the science behind these unique plant fibers, and how you can get more of it in your diet.
What are beta-glucans?
Beta-glucans are a type of fiber found in the cell walls of certain yeasts, bacteria, fungi, algae (like seaweed), along with other plants like oats, barley, wheat, rye, and mushrooms. Beta-glucans serve as a source of energy and structure in these various plant species.
Most grain-based beta-glucans are soluble fibers, which means they dissolve in water and are typically fermentable (i.e., prebiotic) in your digestive tract. Beta-glucans from bacteria, fungi, and yeast are typically insoluble in water.
Health benefits of beta-glucans.
May promote heart health.
Kristin Gillespie, M.S., R.D., L.D., CNSC, explains that improved heart health is likely the most well-known benefit of beta-glucans. "Studies have identified improvements in total and LDL cholesterol levels with beta-glucan intake; these lipids are among the top risk factors for heart disease," she says. "The FDA has actually designated a heart-health claim for foods that are rich in beta-glucan based on this evidence."
That FDA heart-health designation is specific to a food-based dose of beta-glucans (i.e., 3 grams or more) from whole oats or barley, in the context of a diet low in saturated fats and cholesterol. And as these meta-analyses of randomized controlled trials demonstrate, the science backs beta-glucans' (from oats3 and barley4) ability to improve key heart-healthy lipids.
Can support immunity.
Linda Quinn, M.D., FAARM, calls beta-glucans "one of the most powerful immune-supporting phytochemicals." The research indicates that these bioactive polysaccharides can positively affect your immune system in a few unique ways.
In a comprehensive 2020 review published in Molecular Nutrition and Food Research, researchers examined the immune-support role of a specific type of beta-glucans (beta-1,3/1,6-glucans) from baker's yeast (Saccharomyces cerevisiae) in preclinical and human studies to date.
The science demonstrates that beta-glucans have antioxidant properties and are potent immunomodulators: They help train and strengthen the innate defense functions of key immune cells like neutrophils and macrophages. These essential white blood cells help protect you from immunologic threats and infection.
Beta-glucans also help balance inflammation, a critical component of your body's immune response. Finally, yeast-derived beta-glucans have been shown to have a protective and symptom-reducing impact on upper-respiratory-tract infections5 (URTI), such as colds and the flu.
Support gut health.
Because certain beta-glucans (e.g., from oats and barley) are soluble fibers, they absorb water throughout the intestinal tract and bulk up stools, helping to promote regularity by improving constipation and diarrhea. Beta-glucans also act as prebiotics6, feeding the good bacteria in your gut and helping balance your gut microbiome.
Promote glycemic control.
Like other soluble fibers, beta-glucans can have positive effects on a key metabolic health parameter: your blood sugar. Collective data from randomized controlled clinical trials in those with diabetes demonstrates the ability of beta-glucans to improve blood glucose levels9 and glycemic control10 as measured by HbA1c. (It's important to note that these studies were using a hefty dose of 2 to 6 grams of beta-glucans over many weeks.)
Can support longevity.
While most of the studies on beta-glucans and aging or life span have been conducted in animal models, longevity is another potential benefit worth mentioning. Again, the evidence is in its early, exploratory stages, but in one study published in Rejuvenation Research11 in 2020, researchers found that beta-glucans exerted anti-aging effects on fish by promoting antioxidant activity, reducing oxidative stress, and helping fight off infection.
Of course, with the important role of beta-glucans in metabolic health and immunity in humans, one could extrapolate that these important plant bioactives may contribute to healthy aging in us, too! More research will help to fully inform this hypothesis.
As topical treatments for skin.
While many of the benefits of beta-glucans come from consuming them, there may be some benefit to putting it on your skin, too. In addition to its ability to permeate skin, potential mechanisms that make beta-glucans an excellent cosmetic candidate12 include its antioxidant, anti-wrinkle, and moisturizing properties.
There's a relatively small amount of research on beta-glucans as a topical treatment. But some laboratory studies have shown that, when applied to both acute and chronic wounds, this plant fiber accelerated the healing process13 by controlling inflammation, contributing to the growth of new skin, and fighting off bacteria and other viruses that can cause infection.
What are the best sources of beta-glucans?
So, how do you make sure you're getting enough beta-glucans in your diet? You can start with these high-fiber foods:
- Whole grains
- Baker's yeast
- Mushrooms (reishi, shiitake, maitake)
"Aside from consuming a bowl of oatmeal as we generally think of it, you can add oats to smoothies, protein shakes, or baked goods to increase your beta-glucan intake," recommends Gillespie. "Oat flour can be utilized in place of regular flour in baking. Barley is also rich in beta-glucan; consider utilizing pearl barley in place of other starchy side dishes, such as rice."
Quinn recommends combining different sources of beta-glucans, or "bundling it for the boost," so you can benefit from the synergy of plant phytochemicals. "Pack your smoothie with multiple mushrooms and fruits rich in antioxidants, such as blueberries or dark cherries, to mask the intense mushroom flavor," she says. "Soups are another easy way to consume beta-glucans and also add some sparkle to your meal. You can make a shiitake broth (dashi) with some kombu as an excellent healing broth."
The science: How beta-glucan provides benefits.
But how exactly do beta-glucans work? Well, it depends on the health benefit14 we're talking about. For immune health, beta-glucans are antioxidant immunomodulators that help train our innate immune defenses and balance inflammatory responses.
For gut health15 and cardiometabolic benefits (i.e., lowering cholesterol3 and improving glycemic control10) from oats and barley, the biological mechanism is rooted in the fact that they're soluble fibers. This means beta-glucans pull in water from the gut and form a viscous, gel-like substance, slowing down the transit of foods (and absorption of their components, like glucose and cholesterol) through your digestive tract.
"This is how it regulates blood sugar levels, as sugar gets absorbed into the bloodstream more gradually," says Gillespie. "Beta-glucan is also indigestible by the body; this means that it passes through the GI tract without being broken down and absorbed. As it travels intact through the GI system, it can carry excess lipids, like cholesterol out with it."
What are the potential side effects?
There's a lot of existing foundational science and future promise surrounding the health benefits of beta-glucans. Supplementation research using beta-glucan concentrate or extracts is an active area of growing research, especially for immune health, in children and adults.
Beta-glucans are very well tolerated and have a strong record of safety. In clinical studies using beta-glucans from oats or barley, no adverse side effects16 have been observed in children or adults. And the same safety has been shown across the life span for beta-glucan extracts from yeast, too.
One potential drug-nutrient interaction to mention is immunosuppressants. Because beta-glucans promote and stimulate the immune system, a person on immunosuppressant drugs should discuss any plans to significantly increase their beta-glucan intake with their health care practitioner. Of course, it's always a good idea to consult with your doctor before making any major lifestyle changes, especially if you take any medications.
Beta-glucans are unique plant fibers that have been connected to better gut health, increased immunity, and improved cardiometabolic health parameters. These add up to a healthier life overall. Oats, barley, yeast, and mushrooms are the primary food sources of beta-glucans, but you can also find them in supplemental form for a targeted approach.
Lindsay Boyers is a holistic nutritionist specializing in gut health, mood disorders, and functional nutrition. Lindsay earned a degree in food & nutrition from Framingham State University, and she holds a Certificate in Holistic Nutrition Consulting from the American College of Healthcare Sciences.
She has written twelve books and has had more than 2,000 articles published across various websites. Lindsay currently works full time as a freelance health writer. She truly believes that you can transform your life through food, proper mindset and shared experiences. That's why it's her goal to educate others, while also being open and vulnerable to create real connections with her clients and readers.