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Everything You Need To Know About Preventing Mold In Air Vents & Ducts

Michael Rubino
Author:
June 11, 2025
Michael Rubino
Mold Remediation Expert
By Michael Rubino
Mold Remediation Expert
Michael Rubino is a mold and air quality expert and founder of HomeCleanse, a revolutionary company with the vision to end the worldwide health epidemic caused by poor air quality and toxic indoor environments.
Image by Michael Rubino / mbg Creative
June 11, 2025
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If you've ever caught a musty smell when the AC kicks on or wondered why your allergies flare up indoors, your HVAC system, including the air vents and ducts, might be trying to tell you something. Hidden behind vents and tucked away in ductwork, there's a part of your home that rarely gets noticed—but it plays a huge role in your indoor air quality.

What happens when that system becomes part of the problem instead of a modern benefit, though?

Let's dive into one of the most overlooked but important places mold can grow and what you can do to catch it, clean it, and keep it from coming back. Because when it comes to the air you breathe every day, what you don't see can absolutely affect your health.

What are air vents and air ducts? 

The HVAC system is essentially the lungs of the home. The air vents and ducts are the pathways through which air flows in and out, keeping your indoor environment comfortable, whether you keep your house at 75 or 65 degrees. 

Just like the airways in your body, these components work together to circulate air throughout your home. Here's a birds-eye view of each one: 

  • Air vents are visible openings in walls or ceilings where air enters or exits. They're where the heated or cooled air from your HVAC system is released into the rooms and also where air is sucked back into the system to be filtered and recirculated. Think of these as the mouth and nose of the body.
  • Air ducts, on the other hand, are the hidden network of tubes that run behind walls, floors, and ceilings. They carry air from your HVAC system to the vents and back again, ensuring every room gets the airflow it needs. Think of this as the respiratory tract, taking air to the lungs.

Together, air vents and ducts ensure that your HVAC system can distribute air throughout your home efficiently. But when these pathways get clogged, dirty, or contaminated, they can cause far more harm than good, affecting both your home's air quality and your health.

What happens when they become contaminated 

Mold and contamination in vents and ducts can lead to a variety of problems and are a massive home health issue. 

Here's why we want to avoid this particular problem: 

  • It drastically lowers the indoor air quality in the home, leading to a long list of potential health risks. This is the main reason we want to avoid mold in the HVAC system.
  • It can cause structural damage to the HVAC system, including ducts, coils, and insulation.
  • If mold spreads from the HVAC system to other parts of the space, it can damage walls, ceilings, and other structural components.
  • Mold growth can obstruct airflow and reduce the system's efficiency, leading to higher energy bills and decreased performance.
  • A contaminated system may have to work harder to maintain that ideal temperature, leading to increased wear and tear and potentially shortening the system's lifespan.
  • Contaminated ducts must be professionally cleaned or replaced to restore the home to normal ecological levels, which requires a significant monetary investment.

Taken as a whole, preventing issues within this system should be at the top of our priority list for home maintenance and creating a safe indoor environment.

How mold in air vents and ducts can impact your health

What is the main issue with mold in air vents and ducts? Again, it's the effect it can have on the health of those inside the building.  

A contaminated HVAC system will pump air packed full of mold spores and fragments to every part of your home that the system is designed to heat and cool. Some species also release microscopic particles called mycotoxins that are particularly toxic to the human body. 

The longer the contamination exists in the system, the more polluted your air and home will become. The microbial volatile organic compounds (mVOCs) released by active mold colonies often release that telltale musty odor and can also cause a litany of health impacts. 

Exposure triggers a multisystemic immune response, so symptoms can span the entire body. Some symptoms include: 

  • Headache 
  • Fatigue 
  • Brain fog
  • Muscle and joint pain
  • Skin sensitivity and rashes 
  • Hair loss
  • Hormonal imbalances 
  • Anxiety and depression 
  • Respiratory distress 
  • Digestive issues 
  • And more…

Everyone responds differently to mold exposure due to a variety of factors, including species, presence of mycotoxins, health of the immune system, and genetics. While one person may have no symptoms, another may develop over a dozen. 

Certain chronic conditions can also develop, including asthma, allergic fungal sinusitis, allergic bronchopulmonary aspergillosis, chronic fatigue syndrome, mast cell activation syndrome, and more. That's why all microbial growth in a home should be taken seriously and dealt with quickly and correctly.

How does mold in air ducts and vents occur? 

Mold spores are naturally present in the air and can easily enter your home's HVAC system. These microscopic particles remain dormant until they find the right conditions to grow: moisture and an organic food source.

There are several potential sources of moisture in HVAC systems:

  • Humidity: Some species of mold can develop in humidity that's 60% and above, so excess humidity fuels microbial growth. High humidity also allows moisture to collect on coils, drain pans, and duct walls. 
  • Poor airflow: Limited airflow causes stagnant air pockets and increases humidity inside ducts. Common causes include blocked vents, dirty filters, or unbalanced duct design.
  • Improper sealing: Gaps or cracks in ductwork let humid, contaminated air from crawl spaces, attics, or basements enter the system. This introduces moisture and mold spores while reducing efficiency and humidity control for the entire home. Most homes leak 20-30% of the air through their ductwork.
  • Improperly sized unit: An oversized system short cycles and doesn't run long enough to dehumidify the building. An undersized unit may run constantly but still fail to remove enough moisture. Both lead to condensation and the potential for mold in the air vents and ducts.
  • Improperly sized ductwork: Ducts that are too narrow restrict airflow; ducts that are too wide slow it down. Either issue disrupts humidity control and creates uneven temperatures and condensation risks.
  • Uninsulated or poorly insulated ductwork: When ducts in unconditioned spaces aren't properly insulated, temperature differences cause condensation. Moisture builds on duct surfaces and promotes mold, especially if airflow is weak.
  • HVAC components: Coils, drain pans, and condensate lines naturally collect moisture. If clogged, cracked, or dirty, they hold water and organic matter—creating a prime breeding ground for mold. Regular maintenance is essential for preventing this from occurring.

From there, dust—a common contaminant in HVAC systems—provides mold with ample organic material to feed on, including dead skin cells, pollen, and pet dander.

Determining if there's a contamination situation 

If you think you're dealing with mold in air vents and ducts, you can take several initial steps to determine if there's a problem and then more in-depth steps to determine the extent of said problem. 

Step 1: Conduct a DIY test 

If you simply want to check for a problem or think there might be one, start with a DIY inspection. Take a look at the HVAC system itself, the supply vents, and the return vents. If possible, remove a vent cover and shine a flashlight into the ductwork. Just make sure that you're wearing a mask and gloves during this process. 

Look out for these common indicators:

  • Visible mold growth: Over 100,000 species of mold have been identified, so look for any sort of colored growth patches around air registers, vents, or HVAC components. They may appear fuzzy, powdery, or slimy.
  • Musty odor: A persistent, earthy, damp, musty, cigar-like smell from your vents.
  • Health symptoms: Chronic headaches, coughing, fatigue, brain fog, or any other ongoing symptoms without a clear cause.

A few other signs to pay attention to include: 

  • Water leaks or condensation issues: Persistent moisture around your HVAC system.
  • Reduced system efficiency: Mold buildup can hinder airflow and reduce HVAC performance.

If you see a visual indicator, skip to step 3, hiring a qualified medical professional. On the other hand, if you still suspect an issue or want to ensure your indoor environment is healthy, move on to step 2.

Step 2: Conduct a dust test 

Gravity brings particles like mold spores, mycotoxins, and endotoxins down to horizontal surfaces like floors, doorframes, and furniture. So, basically, where dust collects, so do these indoor contaminants.

Testing this dust will help to determine exactly what's hanging out in your home and potentially causing problems. Highly contaminated dust is not only a health hazard, as all of those particles can enter the body when they're kicked up into the air when the dust is disturbed. It also indicates that there's an underlying contamination problem somewhere in the home, and it could exist within the HVAC system.

A product like The Dust Test will help you know if there's a problem before spending thousands of dollars trying to find one (both medically and in your home). And, if there is a problem, The Dust Test will indicate what you're being exposed to before your inspector comes so that you can ensure they will find where it's coming from—including your air vents and ducts.

If these results show an issue, you can hire a mold inspector to better determine what's going on inside your home and make a plan of action.

Step 3: Hire a qualified mold inspector 

A qualified mold inspector sets the foundation for success in properly handling a contamination situation. The data they collect will help create the comprehensive protocol needed by the remediation team to handle the toxic situation appropriately.

When you're looking for a mold inspector, don't be afraid to ask questions. What kind of experience do they have? Are they trained to work with people who are more sensitive to environmental exposures? What kind of tests will they run? Will they provide a clear plan for the remediation team based on the results?

The answers will help you figure out how seriously they take this kind of work—and whether they'll be thorough enough to get to the root of the problem. A proper inspection should take at least a few hours, cover the entire home, and include multiple testing methods to fully understand what's going on.

Key data you should expect to receive include:

  • Mold species and quantities
  • Mycotoxin presence
  • Spore activity in the HVAC system

All of this helps determine what steps are needed to properly remediate and fix the problem. For example, if mold spores are found in the HVAC, that system has to be cleaned. Otherwise, it can spread those particles throughout the home and potentially start new mold growth.

At the end of the day, successful remediation means having all the right information up front so the job can be done correctly the first time.

Your guide to handling mold in air vents and ducts 

If mold is suspected in your air vents or ductwork, the first step is to bring in a NADCA-certified contractor. They're trained to assess HVAC systems and will know what parts of the ductwork can be cleaned and what needs to be replaced.

Here's a quick breakdown of how different types of ductwork hold up when it comes to cleaning:

  • Flexible ductwork is technically made from nonporous plastic, but it's nearly impossible to clean. The friction in the material traps particles, so contamination tends to stick around no matter what.
  • Metal ductwork—like rigid sheet metal, galvanized steel, or aluminum—can be thoroughly cleaned and remediated.
  • Fiberglass-lined ducts aren't cleanable as is, but in some cases, the fiberglass can be removed, the ducts cleaned, and new lining installed to prevent condensation ("duct sweating").
  • Fiberboard ducts can't be cleaned at all. These need to be fully removed and replaced.

If any parts of the ductwork need to be replaced, the process includes:

  • Removing the contaminated material
  • Remediating the surrounding area
  • Installing new, clean ductwork
  • Having an HVAC professional clean and inspect the system itself
  • Deep cleaning the entire home

Keep in mind, ductwork is often hidden behind walls or ceilings, so accessing it may require opening up parts of the home.

During the cleaning process, the contractor should put the system under negative pressure—using a HEPA-filtered vacuum system—to minimize the spread of mold particles during removal and cleaning. Think of it like a giant air scrubber that helps contain what's being stirred up.

Some particles (usually around 10–25%) can still escape even with negative pressure. That's why it's important to deep clean the entire home afterward. No HVAC system is perfectly sealed, and if someone in the home is particularly sensitive, it may also be necessary to replace porous materials (carpets) that have absorbed contamination.

Tips to prevent mold in these areas

Avoiding mold in air vents and ductwork should be a top priority to avoid the headache above. 

Here are some tips to get you started down the right path: 

  • Upgrade to the highest-rated MERV filters your unit can handle, or invest in a whole-home air purifier that can handle highly rated filters with the pressure drop of lower-rated MERV filters.
  • Change air filters on time, according to the manufacturer's recommendation.
  • Routinely check filters to make sure they're not dirty or clogged.
  • Get the unit serviced twice a year (spring and fall) by a certified HVAC professional.
  • Monitor the evaporator coil to make sure it doesn't freeze over, which can lead to water buildup.
  • Check the drip pan regularly to avoid standing or overflowing water.
  • Make sure your HVAC system is the right size and that all components are adequately insulated.
  • Use exhaust fans in moisture-prone areas like bathrooms, laundry rooms, and kitchens to vent out humid air.
  • Keep indoor humidity between 35 and 50%—mold can start growing at levels above 60%.
  • Seal ductwork properly to prevent humid air from leaking in and to avoid contamination.
  • Avoid blocking vents and returns with furniture or clutter, which can restrict airflow and increase condensation.
  • Fix leaks quickly, whether it's a dripping pipe or roof issue—excess moisture can spread to HVAC components.
  • Use a dehumidifier in damp areas of the home, like basements or crawl spaces, to reduce overall moisture levels.

Breathing easier

When it comes to mold in your HVAC system, knowledge is one of your best defenses. It's not just about keeping your home looking and feeling clean—it's about protecting your health and the well-being of everyone in your home. 

Mold can easily go unnoticed when growing in places like air vents and ducts, but that doesn't mean out-of-sight, out-of-mind. The good news is that with the right steps, it's absolutely something you can take control of.

By understanding how and why mold can develop in HVAC systems, and by working with qualified professionals, you're setting yourself up for success. Whether it's through regular maintenance, upgrading filters, or checking for hidden moisture, every small effort adds up to a safer, healthier home.

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