You Probably Need More Glutathione Than Even A Healthy Lifestyle Can Offer
With a nickname like "the master antioxidant," glutathione is a one-of-a-kind bioactive that deserves your attention. Even if you've never heard of it before, this powerhouse compound is hard at work throughout your body in order to help you feel your best. Thing is, glutathione can only have its full impact if you've got ample amounts of it—and while your body can produce its own stash of the antioxidant (with some help from you in the form of a healthy diet and lifestyle), you might not be churning out enough to keep up with the stresses of modern living.
Here's what you need to know about glutathione, what it does for your health, and how to make sure you're getting what you need.
What is glutathione — and what does it do in the body?
Glutathione is an antioxidant that's made up of the three amino acids—glutamine, glycine, and cysteine—all of which are rich in the mineral sulfur. The main functions of glutathione are to fend off free radicals—or unstable molecules that can stress your cells and/or DNA—in order to control oxidative processes, as well as to remove toxins from the body.*
According to functional medicine doctor and mbg Collective member Mark Hyman, M.D., the sticky, flypaper-like nature of the sulfur in glutathione is what allows it to essentially grab on to free radicals and toxins (like mercury and other heavy metals) in order to usher them out of the body.*
Left unchecked, free radicals and oxidative stress contribute to a variety of health concerns, as well as the aging process.
The benefits of glutathione.
Considered "at the apex" of various protective antioxidant compounds (like vitamins C and E), glutathione's roles and benefits spread far and wide throughout the body.* Here are a few of the most notable:
No surprise here considering all that talk earlier about glutathione being like flypaper for free radicals and toxins, right? It's worth restating, though: According to Hyman, glutathione is a critical and integral part of the body's intrinsic detoxification system. "Toxins stick onto glutathione, which then carries them into bile and the stool to discard,"* he told mbg.
Also unsurprising given its role in detoxification: The highest concentrations of glutathione in the body are found in the liver and kidneys.
One Frontiers in Immunology study suggests that glutathione helps "fine-tune" our immune response, helping the body to respond effectively when needed without kicking into unhelpful overdrive.* In addition to this role in daily immune function, Hyman also suggests that ample glutathione is crucial for long-term immunity, as well.*
Glutathione also works to maintain the epithelial tissues (the lining found in organs like the intestines), which act as barriers between compounds ingested by the body and the bloodstream and are crucial for maintaining immune balance.*
It even works to support the production of various cells that are essential for our immune response, including T-cells and natural killer cells, both lymphocytes (aka white blood cells).*
"Glutathione is naturally produced by the liver and works in that organ to combat toxins and turn them into bile,"* explains Toronto-based dietitian Abby Langer, R.D. This pungent stuff then plays a role of its own: It's actually a must-have for the optimal digestion of fat, she explains.*
Of course, properly functioning epithelial tissue throughout the digestive tract is also important for the digestion and absorption of the nutrients we consume.
Brain health and function
Another indicator of glutathione's widespread importance throughout the body: Low levels in the brain have been linked to suboptimal cognition and brain health, according to an International Journal of Molecular Sciences review.* Research suggests that glutathione helps maintain a fragile balance that affects the function of neurons throughout the brain.* It's also especially important because brain tissue is largely constituted of unsaturated fatty acids, which are highly susceptible to oxidative stress.*
Whole-body wellness & longevity
Ultimately, glutathione's function within the body is so powerful that it's been identified as vital for overall health and longevity.* In fact, large-scale research published by Biological Chemistry has connected low levels with everything from suboptimal liver and reproductive health to changes in metabolic function and mental well-being.*
Because of its interactions with the immune system, healthy levels of glutathione contribute to the body's overall balance or homeostasis, supporting an overall environment that's favorable for maintaining long-term health.*
Sources of glutathione.
There are two primary ways to make sure you're getting enough glutathione, and they're complementary. One is through diet and lifestyle, and the other is by supplementing. Here's what to know about each of them.
Diet & lifestyle
There are some foods that naturally contain glutathione—fruits and vegetables have moderate amounts, while freshly prepared meats are high in the antioxidant.
In addition to eating a diet rich in produce and consciously raised animal proteins, Hyman also recommends including sulfur-rich foods like garlic, onions, and cruciferous vegetables (think broccoli, kale, cabbage, cauliflower, and collard greens) in your daily diet. Since sulfur helps your body make glutathione, eating these foods regularly can contribute to keeping your levels in a good place.
And since glutathione consists of three amino acids, it's also important to eat adequate protein, which ensures that your body has an ample pool of amino acids to produce glutathione from.
That said, thanks to stressors, like poor diet and/or regular exposure to toxins through food, household products, or our environment, our daily demand for glutathione may be higher than what we can support through food, according to Hyman. Basically, the more stressed you are, the more glutathione your body uses up. Because of this, you may want to consider taking a glutathione supplement (more on that later) to ensure your body gets as much as it needs, he suggests.*
Other important factors that come into play are exercise and sleep, since not getting enough of either is linked with lower glutathione levels, Hyman notes. So, if exercise isn't already a daily habit, build up to 30 minutes of sweat-inducing aerobic activity every day and 20 minutes of strength training three times per week. As for sleep, seven to nine quality hours per night is a good, science-backed goal.
In case you're wondering whether glutathione supplements can really move the needle, research shows that they can make a major difference in serum levels of the antioxidant in the body.*
In fact, evidence from a groundbreaking clinical trial published in the European Journal Of Nutrition demonstrates that daily glutathione supplementation over six months in healthy adults is bioavailable to our bodies and effective at increasing levels in the circulation (aka, our blood).* Furthermore, this supplement regimen translates directly into elevated stores of this master antioxidant in red and white blood cells.*
What's more, these improvements in glutathione status in the body were accompanied by less oxidative stress and improved natural killer cell activity (hello, immune function).*
In other words, a daily addition of targeted glutathione supplementation helps ensure our body compartment stores of this whole-body relevant tripeptide powerhouse remain sufficient enough to maximize whole-body antioxidant balance and immune health benefits.*
With that in mind, know that just how much glutathione per day might be optimal for you varies greatly depending on individual factors, including the stressors you're dealing with, your age, and lifestyle factors such as drinking and smoking habits. mbg formulated daily detox+ to not only provide 250 milligrams of vegan Setria® glutathione from microbial fermentation (which is clinically backed for bioavailability and efficacy), but four additional powerhouse ingredients that support the body's natural detoxification pathways as well: milk thistle, NAC, selenium, and acerola fruit vitamin C.*
While each of these ingredients delivers specific detoxifying actions, the formula is intentionally synergistic, since all four support and elevate glutathione by promoting its production (milk thistle), bolstering its levels in the body (vitamin C), aiding in the activation of glutathione enzymes (selenium), and supporting glutathione's replenishment (NAC).*
Any concerns with glutathione?
Known for its high safety profile, there haven't been any major documented concerns with taking glutathione. However, one study focusing on cosmetic outcomes noted the potential for itchy skin, temporary rashes, and tiredness—though it's worth mentioning that all of these minor side effects were also seen in the placebo group, too, so the role of glutathione in these "side effects" is questionable at best (and not statistically significant). Nevertheless, it's always a good idea to partner with your doctor or a trusted health care professional before adding something new to your routine.
Glutathione is a master antioxidant and critical regulator of oxidative stress, natural detoxification, and immune function, having far-reaching impacts throughout the body and various areas of health and well-being.* Though a nutrient-dense diet and healthy lifestyle support glutathione levels, our ability to produce the antioxidant on our own doesn't always stack up to the increased needs that often come with modern living. In these cases, incorporating a glutathione supplement (or a targeted multi-ingredient supplement that optimizes glutathione's health benefits, like mbg's daily detox+ does for natural detoxification) can provide additional support on the daily.*
Lindsay Boyers is a holistic nutritionist specializing in gut health, mood disorders, and functional nutrition. Lindsay earned a degree in food & nutrition from Framingham State University, and she holds a Certificate in Holistic Nutrition Consulting from the American College of Healthcare Sciences.
She has written twelve books and has had more than 2,000 articles published across various websites. Lindsay currently works full time as a freelance health writer. She truly believes that you can transform your life through food, proper mindset and shared experiences. That's why it's her goal to educate others, while also being open and vulnerable to create real connections with her clients and readers.