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Collagen Types: The Important Differences Between I, II & III

Author:

Shawn Radcliffe

Medical reviewer:

Wendie Trubow, M.D., MBA

April 22, 2020

Contributing writer

By Shawn Radcliffe

Contributing writer

Shawn Radcliffe is a science writer who received a B.A. in writing and a B.S. in biological sciences from the University of Pittsburgh, and a master's in Science Education from Drexel University.

Medical review by

Wendie Trubow, M.D., MBA

Functional Medicine Gynecologist

Wendie Trubow is a functional medicine gynecologist with almost 10 years of training in the field. She received her M.D. from Tufts University.

April 22, 2020

Collagen is a highly abundant protein that is present throughout the body, where it helps maintain the shape of tissues and organs. The exact location it shows up in—and the amnio acids it contains—is dependent on the type. The most common are types I, II or III.

To support their collagen levels, people often reach for collagen supplements, which are used for skin, hair, joint, and bone health.* When choosing a collagen—be it grass-fed bovine or marine—you should look for what types of collagen it contains to see if it matches up with your needs.

Type I: Good for skin, hair, and bone health.

Type I collagen is the most common in the body, and it provides structure to skin, tendons, bones, ligaments, and other connective tissues. You can find it in both marine and bovine collagen supplements. It is especially abundant in the skin, where it's "responsible for keeping it pliable and young-looking," says Gretchen Frieling, M.D., a board-certified dermatopathologist.*

As a supplement, this type of collagen is especially beneficial for the skin.* One small study showed that when people took an oral supplement containing mainly hydrolyzed type I collagen 1, after 60 days their facial lines and wrinkles appeared smoother, and the skin maintained healthy moisture levels.* Another meta-analysis study—this one with 805 participants, making it one of the largest to date—showed that the use of oral collagen supplements can promote healthy skin aging by supporting the elasticity and hydration of the skin.*

If you're taking a collagen supplement, you're getting type I collagen. However, most collagen supplements contain two types of collagen in them: those being type II and III. That's where the differences start to show up, as they have very different functions.

Type II: Good for joint health.

Type II collagen occurs in the cartilage found in the ribs, nose, larynx, and trachea. It also shows up in a special kind of cartilage found on many joint surfaces.

Fran E. Cook-Bolden, M.D., a board-certified dermatologist, says this type of collagen "supports joint health, but it hasn't really been shown to be that beneficial for the skin."* It may also work to manage symptoms of joint-related conditions such as osteoarthritis.* This type of collagen is found in marine collagen but not grass-fed bovine.

One randomized clinical trial found that people who took a type II collagen supplement for 180 days saw support in their physical function and helped maintain pain and joint stiffness.* Another meta-analysis, which combined data from five previous studies, found that these collagen supplements supported joint stiffness 2 in people with osteoarthritis, but it didn't improve their pain or physical function.

Type III: Good for skin health

Type III collagen works alongside type I in skin, ligaments, blood vessels, and joints too. Type III collagen is found in grass-fed bovine collagen but not marine. This type of collagen "promotes skin health and elasticity—or what gives you that bounce-back in the skin," says Cook-Bolden.*

Few studies, though, have looked at taking type III exclusively—or at least in the same way that there's been research done on type I and II—but some overall research points to the benefits of type III collagen. Most notably, research has found that type III collagen content in skin decreases with age; type I also decreased, but to a lesser degree, perhaps implying that type III might be more of a key factor in skin aging. While we don't know for sure if this is the case, we do know that type III collagen is very important for fibroblast function 3.* Fibroblasts are what help us produce collagen itself, as well as elastin. These are vital in wound healing and overall skin health.*

The bottom line.

Of the collagen supplements out there, collagen types I, II, and III are the most prevalent—they are also the most prevalent in our bodies. And each type plays a different role, meaning that it's important to know the difference when choosing what collagen supplement is right for you. Obviously other factors come into play—diet, being the main concern—but if you are looking for a more skin-supporting and full-body benefit supplement, you should consider a grass-fed bovine collagen.*

If you are pregnant, breastfeeding, or taking medications, consult with your doctor before starting a supplement routine. It is always optimal to consult with a health care provider when considering what supplements are right for you.