What Brazilian Supercentenarians Can Teach Us About Living To 110

The longevity world loves a flashy promise. Live to 150. Reverse aging. Biohack your way out of death. Scroll social media for five minutes, and you’ll see people chasing immortality with cold plunges, ultra-expensive diagnostics, and carefully engineered lifestyles meant to slow time itself.

And yet, in Brazil, something very different is happening.

Without access to luxury longevity clinics or experimental anti-aging therapies, many Brazilians are routinely living to 100, 105, even past 110. In fact, Brazil is home to three of the ten longest-lived men in recorded history, including the world’s oldest living man, born in 1912. What’s even more remarkable is that many of these individuals remained independent, cognitively sharp, and relatively healthy well into extreme old age.

Researchers have long studied centenarians because they represent something rare: people who have managed to avoid or delay many of the major diseases of aging, including heart disease, cancer, and dementia.

Brazil offers a particularly unique opportunity. The country has one of the most genetically diverse populations in the world, shaped by centuries of Indigenous ancestry, African heritage, European immigration, and a large Japanese population. This rich genetic diversity creates biological patterns that don’t appear in more genetically homogeneous populations, and many of these patterns are still missing from global genomic databases.

Scientists are studying over 100 Brazilian centenarians, including 20 supercentenarians, to understand what keeps them thriving. The research reveals three key biological advantages that set these individuals apart from typical aging patterns.

One of the most striking findings involves protein maintenance, sometimes called cellular housekeeping. As we age, our bodies become less efficient at clearing out damaged or misfolded proteins. That breakdown contributes to inflammation, neurodegeneration, and loss of function.

Supercentenarians appear to defy this decline. Their cells maintain protein quality control systems—like autophagy and proteasome activity—at levels similar to much younger adults. In simple terms, their cells stay better organized and less cluttered over time.

The immune system tells a similar story. Instead of a steady decline, the immune systems of supercentenarians seem to adapt. They show signs of resilience rather than exhaustion, with immune cells that remain effective at fighting infections and managing inflammation. Some even display unconventional immune profiles that appear protective later in life.

Most of us weren’t born in Brazil, and we don’t get to choose our genetics. But this research reinforces something longevity science keeps circling back to: healthspan matters more than lifespan.

The story unfolding in Brazil is a reminder that longevity isn’t only built in labs or luxury clinics. In many cases, it’s shaped slowly, through resilient biology, daily movement, and strong muscles.