The Surprising Way Magnesium May Help Protect Against Colon Cancer

With the recent heartbreaking losses of James Van Der Beek and Catherine O'Hara, many have been opening up about their colorectal cancer diagnoses. Colorectal cancer rates are rising, especially among younger adults, and it's a shift researchers are scrambling to understand.
While screenings and lifestyle factors like diet and exercise remain the foundation of prevention, new research points to an unexpected player in the fight against colon cancer: magnesium. Specifically, how this essential mineral affects your gut bacteria, and, in turn, your body's ability to produce vitamin D.
What the new research found
A study published in The American Journal of Clinical Nutrition1 offers some compelling insights. Researchers ran a rigorous trial to see how magnesium supplements affect the gut.
The key finding? Magnesium supplementation helped increase two types of beneficial gut bacteria that do something pretty cool: they produce vitamin D right there in your gut and may help protect against colon cancer.
There was also a genetic component — the benefits were strongest in people with a certain gene variation that affects how the body handles magnesium. And interestingly, the effects were particularly notable in women.
The magnesium-gut-vitamin D connection, explained
To understand why this research is exciting, it helps to know how vitamin D works in your body.
Most people get vitamin D in one of three ways: sunlight (your skin makes it when exposed to UV rays), food (fatty fish, egg yolks, fortified milk, and cereals), or supplements. However, many of us still don't get enough. Limited sun exposure, northern climates, spending more time indoors, and dietary gaps all contribute to widespread vitamin D insufficiency.
That's what makes this gut bacteria discovery so intriguing. It turns out certain bacteria in your digestive system can actually produce vitamin D on their own — creating a fourth pathway your body can use.
It's magnesium that seems to help the vitamin D-producing bacteria thrive. So when you're getting enough magnesium, you're creating a better environment for these helpful microbes. And when they're happy, they produce vitamin D that may help keep your colon healthy.
Think of it as a chain reaction: magnesium feeds the good bacteria, those bacteria make vitamin D, and that vitamin D may help protect against cancer.
A few things to keep in mind
A few caveats are worth noting:
- This is one study. The results are promising, but we need more research to see the full picture.
- Your genes matter. The benefits were strongest in people with certain genetic traits, so results may vary.
- This isn't a replacement for screenings. Colonoscopies and other screenings are still the gold standard for prevention and early detection.
- Talk to your doctor. Before starting any new supplement, check in with your healthcare provider.
How to get more magnesium in your diet
Plenty of everyday foods are packed with magnesium:
- Leafy greens like spinach and Swiss chard
- Nuts and seeds such as pumpkin seeds, almonds, and cashews are great options
- Legumes including black beans, chickpeas, and lentils
- Whole grains like quinoa and brown rice
- Dark chocolate (look for 70% cacao or higher)
Signs you might be running low on magnesium include muscle cramps, fatigue, poor sleep, and irritability. If any of these sound familiar, it might be worth evaluating your intake.
If you opt for a supplement, magnesium bisglycinate is a well-absorbed form and typically won't cause much digestive upset.
The bottom line
Colorectal cancer prevention isn't about one magic solution. It's about the accumulation of smart, consistent choices over time. Screenings, a fiber-rich diet, regular movement, and now, potentially, adequate magnesium intake all play a role.
This new research adds another piece to the puzzle: by supporting the right gut bacteria, magnesium may help your body produce vitamin D in a way that protects against colon cancer. It's one more reason to make sure you're getting enough of this often-overlooked mineral — whether through food, supplements, or both.

