Creatine Supplements May Improve Cognitive Performance After Sleeping Poorly, New Study Shows

The scene is all too common: You get a handful of hours of sleep, reach for a cup of coffee every few hours, and then still feel sluggish. But a new study published in Scientific Reports shows that something rather unexpected can perk up your brain power1 the day following a horrendous night's sleep. 

Creatine is one of the most studied and used supplements to enhance physical performance—mainly for its role in energy production. 

You see, during times of high energy demand (like working out), creatine can be converted into adenosine triphosphate (ATP), the primary energy source for cells. And as 95% of the body's creatine2 is stored in the muscles, this compound is especially useful in helping your muscles go harder during exercise and efficiently recover afterward.*

However, the remaining 5% of the body's creatine stores are in the brain. And this organ is a major energy guzzler. More and more research is showing how taking creatine daily also supports high-energy cognitive tasks3.* And we all know (and feel) that after a poor night's sleep, our brains don't process information as quickly. 

To do that, researchers had 15 men and women in their mid-20s practice a regular sleep schedule (going to bed at 11 p.m. nightly and waking up at 7 a.m.) for two weeks prior to the study. 

Then, everyone went through two nights of limited sleep in a lab (total lying about three hours): one night taking a high dose of creatine and the other taking a placebo. These lab visits were at least five days apart so participants could sleep regularly and recover between sessions. 

Everyone underwent cognitive tests before taking the placebo or supplement, and at three time points after. 

The kicker with this study, though, is that participants were given a pretty large dose of the supplement. Each participant was given 0.35 gram of creatine per kilogram of body weight. So for a 150-pound individual, that's about 24 grams. 

That amount aligns with what is known as a loading dose4. Dosing to this extent is typically used in the short term to quickly increase the body's creatine access and stores. And after the body is properly "loaded," a daily dose of 3 to 5 grams is resumed.   

There's no shortage of creatine supplements to choose from, but there's none quite like mindbodygreen's creatine+. This formula combines 5 grams of creatine monohydrate with 2 grams of the amino acid taurine, which offers even more physical and cognitive performance benefits.*

While this new study is exciting and further supports creatine's role in cognition, more research is still warranted, and you shouldn't jump into taking that large of a dose daily for energy.