Intestinal permeability, or leaky gut syndrome, occurs when tiny gaps develop between the cells, known as enterocytes, that line your intestinal wall.
These tiny gaps allow substances that should be confined to your digestive tract, such as undigested food particles, bacteria and metabolic wastes, to escape into your bloodstream. Once the integrity of your intestinal wall has been compromised, the bacteria, toxic metabolites, and undigested food that escape into blood stream can be recognized as invaders to your immune system. Your immune system tags these “invaders,” marking them as a threat to your health. This causes an immune response throughout your body that can manifest as irritable bowel, fatigue, migraines, brain fog, arthritis, inflammatory bowel disease, psoriasis, eczema, allergies, and autoimmune disease, to name a few. And every time you are exposed to these substances, your immune system reacts aggressively, inciting an inflammatory response. What can cause leaky gut syndrome?