However, she seemed to contradict this message during her opening monologue on Saturday Night Live's season premiere. She made the Kardashian-Jenners' appearances the butt of many of her jokes.
"We have to be a role model for these little girls, because who do they have?" she said. "All they have, literally, is the Kardashians. And is that a great message for little girls? A whole family of women who take the faces they were born with as, like, a light suggestion? Is that great? No!"
I mean ... valid. The audience roared, because, well, they're the family America loves to hate.
But then Schumer took the joke to the next level by taking a direct dig at Khloe Kardashian and her recent weight loss:
"And like, we used to have Khloe. Khloe was ours, right?" she said. "But then Khloe, she's lost half her body weight. Like Khloe, she lost a Kendall, and we have nothing."
Ouch. Khloe has been very open about working her ass off to lose weight in a healthy way, speaking about it in the media and documenting most of it on Instagram.
So, Khloe addressed Schumer's comments on Twitter, though she didn't explicitly call her out: