The Connection Between Artificial Sweeteners & Autoimmune Disease

The rise of autoimmune conditions is staggering. Millions of people around the world are suffering from unexplained symptoms from undiagnosed autoimmune problems, and even with an official diagnosis, they're given very little options in mainstream medicine.

Statistically, autoimmune diseases are the number one cause of health suffering, with two times more people suffering from autoimmune disease than heart disease.

In the past, I've explained the multifaceted causes for the autoimmune explosion. I've also described some effective tools to put autoimmune conditions into remission. Following through on the theme, I pointed to several of the most common triggers for autoimmune flare-ups.

Since writing those articles, I've received feedback asking what I thought about artificial sweeteners and autoimmune conditions. Are they safe to consume, or are they a potential trigger for autoimmune problems?

Artificial sweeteners such as saccharine (Sweet'N Low), sucralose (Splenda) or aspartame (Equal and NutraSweet) are in many diet and sugar-free drinks and foods, with one of the most popular sources of artificial sweeteners being diet sodas.

Despite years of negative press surrounding sodas in general, a 2013 Gallup poll showed that the majority of adults still drink soda, and a large percentage of that consumption is of "diet" versions.

In my field of study, functional medicine, we are concerned with understanding the underlying triggers and factors of health problems. While there aren't many large-scale studies on the subject of autoimmunity and artificial sweeteners, let's look at what's out there:

One case study from the American Association of Clinical Endocrinologists saw a complete reversal of a patient with autoimmune thyroiditis (Hashimoto's) just by eliminating artificial sweeteners and diet soda! Another study out of the Canadian Journal of Gastroenterology correlated the rise of irritable bowel diseases such as Crohn's and ulcerative colitis with sucralose and its inhibitory effect on beneficial gut bacteria.

Research out of the Journal of Toxicology and Environmental Health also points to sucralose's ability to weaken the microbiome. The artificial sweetener was shown to reduce the good bacteria of the microbiome by up to 50% and raise gut pH levels. This is a plausible correlation for autoimmunity, with the microbiome being 80% of the immune system!

It is important to note that there are also many different artificial sweeteners, and not all are created equally. For example, one sugar alcohol, mannitol, which is used in sugar-free gum, is being studied as an effective treatment for Parkinson's! Science, like life, is nuanced.

So What's The Verdict?

I think we need to take into account biological variability, that everyone is different, with different levels of tolerance to the foods we eat and to our environment. Some people have a genetic tolerance for a lot of stressors, some do not.

Ultimately, every food moves us closer to health or away from it, some faster than others. Clinically, seeing hundreds of autoimmune cases over the years, my experience is to err on the side of caution. In general, I've seen many patients with autoimmune conditions respond very negatively when exposed to artificial sweeteners. Sometimes we don't need research to validate our own experience and logic.

Do you know what 3 health food myths are keeping you sick? Removing them from your diet is key for calming inflammation, healing your gut, and ditching fatigue & poor digestion for good. Register now for functional medicine expert Will Cole’s FREE webinar!

William Cole, D.C., IFMCP

Functional Medicine Practitioner
Dr. Will Cole, leading functional-medicine expert, consults people around the world via webcam at and locally in Pittsburgh. He specializes in clinically investigating underlying factors of chronic disease and customizing health programs for thyroid issues, autoimmune conditions, hormonal dysfunctions, digestive disorders, and brain problems.Dr. Cole was named one of the top 50 functional-medicine and integrative doctors in the nation and is the author of Ketotarian in which he melds the powerful benefits of the ketogenic and plant-based diets.
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William Cole, D.C., IFMCP

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